There is a dedicated team of veterinarians that advocate for the safe, responsible feeding of fresh, raw food for dogs and cats. These vets and other professionals are members of the Raw Feeding Veterinary Society (RFVS). Nicci is also a member of this organization as well and you can learn more about the RFVS here: https://rfvs.info/about-us/
Evidence shows that risk factors for DCM is multi-faceted and is not related to a grain-free diet.
Since 2018, Canine dilated cardiomyopathy (DCM) has been a hot topic in the pet food industry, the veterinary community, the press and among pet owners. Although some veterinarians hypothesized there may be a potential association, there has never been a proven direct link (i.e., cause and effect) to grain-free foods (both over the counter or therapeutic) causing DCM in dogs including the FDA investigation. Unfortunately, the FDA’s original request was for cases involving grain-free pet food only, and that is what people keep sending in (which has resulted in a biased and polluted data pool). Perhaps if the FDA asked veterinarians and the public to send in all cases, regardless of diet, we may have seen something else, like the whole picture or a specific nutrient or lack thereof could be the issue.
In late September 2020, the Food and Drug Administration (FDA) quietly issued an update on the grain-free pet food and canine dilated cardiomyopathy (DCM) investigation that was a far cry from – and far less publicized than – the initial FDA reports and updates back in 2018 and 2019. In other words, the FDA walked back their initial reports implying a causation between grain-free foods and DCM. Unfortunately, this did not make the headlines.
Since the initial reports, Vet-LIRN (the veterinary laboratory network that FDA partnered with for the investigation) closely examined a subset of approximately 150 dogs diagnosed with DCM to identify potential causative and recovery factors. The results show that DCM is indeed a multifactorial issue with potential variables including, but not limited to, breed, age, weight, gastrointestinal disease, atopy, infection (Lyme and Chagas disease) and more. These results are not surprising. Recently, McCauley et al (2020) reviewed over 150 studies which found no cause-and-effect link of grain-free food to DCM (see figure below). In fact, their review found similar variables related to DCM like infections and concurrent diseases.
Dr. Steven Solomon, director of the FDA’s Center for Veterinary Medicine, acknowledged that the “complex scientific messaging” on DCM and diet has contributed to misinterpretation about the safety of a grain-free diet. Dr. Solomon encouraged dog owners to select the diet that works best for their pet’s nutritional needs and previewed more multidisciplinary, scientific collaboration between the industry, veterinarians, scientists, and other researchers that will further the understanding of DCM.
Solomon also acknowledged:
“This is one of our ongoing struggles: choosing terminology that is scientifically accurate, understandable to pet owners and that does not cast a shadow over products that are otherwise known to be healthful and safe. I appreciate the fact that FDA’s voice is the voice veterinarians and pet owners listen to, yet too often our messages have been repeated inaccurately by third parties. The result is that in the internet age of phenomenally fast sound bites, complex scientific messaging is often lost in translation. We have tried to be careful in our messaging, and we recognize going forward not to speak on this topic publicly unless we are clarifying information or have something substantive to share.”
In addition to acknowledging the lack of connection of grain-free foods with DCM and the miscommunication because of oversimplified sound bites, the FDA provided and a new Question and Answer page on November 3rd which reinforced that grain-free diets were not inherently dangerous and that there has been no link between DCM and grain-free diets established. The FDA still recognizes the incidence of DCM and will continue their investigation into non-hereditary factors to better understand the disease. The FDA also acknowledges that they have received reports of non-hereditary DCM associated with BOTH grain-free and grain-containing diets (Q&A #8).
If your veterinarian wants to convert you from your current food to their recommended food, it is important to discuss the science behind the “why?”. In fact, the field of nutrition is evolving and advancing, and consumers and veterinarians can benefit from these conversations and by asking questions that help evaluate true quality of pet foods. The truth is that much of the information available for ALL pet foods revolves around marketing rather than nutrient inclusion and availability, but the good news is that you can help change that. Asking the following questions about the food(s) veterinarians recommend and all pet foods in the marketplace can help raise standards and encourage knowledge sharing based on science rather than marketing:
Asking the veterinarian these key questions, will challenge them to think differently about the food they are recommending and come to the realization that the foods they are recommending may be missing this key critical information. Knowing the answers to these questions will enable you to have an open dialogue and make a more informed decision for your pet. This is no different than human medicine. Keep in mind the DCM debacle was started by lack of information tied to nutrient content and availability of the nutrients. Therefore, asking questions #2 and #3 are critical when choosing the right food for your pet. Additionally, when veterinarians started recommending and moving people to Hill’s, likely they were embarrassed, angry and lost credibility with their clients following one of largest recalls in history tied to Vitamin D toxicity which killed and sickened hundreds of pets (question #4).
DCM is not caused by grain-free foods, regardless what a news headline says – as the data does not support this statement. Rather than blaming an ingredient or set of ingredients for any health concern we should instead be focusing on the nutrient analysis and digestibility of all foods in the marketplace to prevent future problems (including grains and ancient grains). For many of us that have studied nutrition, we know that the nutrient content and availability of those nutrients can be significantly impacted by processing conditions.
Using these questions when choosing a food for your pet you should be able to get answers from the manufacturer or from the veterinarian recommending that food. This will enable both of you to have an open discussion about the nutrition of your pet and more importantly help you become an advocate for what you feed your pet. As always if your pet has any health-related issues you should seek veterinary medical advice immediately.
Dr. Solomon’s Full Statement
Questions and Answers: FDA’s Work on Potential Causes of Non-Hereditary DCM in Dogs
DCM and grain-free pet food: September 2020 FDA update
‘BEG’ pet food and DCM, part 2: Is veterinary bias at play?
‘BEG’ pet food does not equal DCM
McCauley et al. 2020: Review of canine dilated cardiomyopathy in the wake of diet-associated concerns
https://academic.oup.com/jas/article/98/6/skaa155/5857674
Weird science: Published pet food studies not always sound
WSAVA pet food recommendations: Useful or useless?
Pet Nutrition Alliance provides false sense of security
McCauley et al., 2020. Review of canine dilated cardiomyopathy in the wake of diet-associated concerns. Journal of Animal Science. 98, No. 6: 1-20
Link: https://academic.oup.com/jas/article/98/6/skaa155/5857674
Ryan Yamka, PhD, MS, MBA, FACN, PAS, Dipl. ACAS is founder and an independent consultant with Luna Science and Nutrition, and co-Founder of Guardian Pet Food Company. He is board certified in companion animal nutrition by the American College of Animal Sciences and a fellow with the American College of Nutrition. Yamka calls on his extensive background in pet nutrition, and 20+ years developing, formulating and launching dog and cat foods as a senior executive with leading pet food companies. Yamka has received the 2020 Rogue Pet Science Pet Industry Disruptor Award, the 2019 Pet Age ICON Award and the 2011 ASAS Corbin Companion Animal Biology Award. Dr. Yamka writes a series of blogs Debunking Pet Food Myths and Misconceptions for Pet Food Industry and has been featured in numerous podcasts and seminars.
To learn more about Ryan, check his background credentials on LinkedIn (www.linkedin.com/in/ryanyamka)
Do you let your pet kiss your face? We’re guilty! But we’ve heard some say this could be dangerous.
We were curious about where science stood on this behavior, so we consulted experts in both human and animal health to find out how bad it really is to let your pet kiss you on the mouth.
https://www.petnews.com.au/research/how-unsanitary-is-it-to-kiss-your-pet-on-the-mouth/
Though everyone might not agree on cats’ perfection, felines are among the most popular pets in the world today, with approximately 74 million cats living in U.S. homes.
The cat has long been important to human societies as a pest-control agent, object of symbolic value and companions. However, recent evidence from feline DNA shows they took their time domesticating themselves.
There has always been debate about how and what dogs and cats can see. The reality? Dogs & cats don’t see as clearly as humans, and they’re lacking in the color department. However, they can see movement better than we can.
One Health is an approach that recognizes that the health of people is closely connected to the health of animals and our shared environment.
The World is changing, COVID has accelerated that change in countless ways. I believe that the unprecedented collaboration between disciplines and scientists from all over the world will be looked at as one of the most incredible feats in our modern world. My hope is that this collaboration (and open access to scientific literature) continues and inspires other professionals to integrate their practices and their knowledge to work together to improve the lives of humans, animals and the environment. In fact, there is something called the One Health Initiative which aims to do just that.
So, what does this mean for us and our pets? What does it mean for nutrition? The reality is that there are numerous research gaps when it comes to nutrition, and even more when it comes to companion animal nutrition. The environment and how we interact with it also has a significant impact on the health of all living things. Much of the research we rely on for canine and feline supplementation, or management of disease is rooted in human research.
Many medical and nutrition professionals have recognized these significant gaps in human and animal medicine and nutrition. Livestock nutrition is arguably the most advanced of all nutrition sciences, followed by human nutrition, and it is frustrating to see the lack of knowledge sharing & collaboration between those and companion animal fields. This is a significant issue because it leaves treatment gaps for canines and felines such as cognitive dysfunction, allergies, gastrointestinal issues, diabetes, heart disease and more.
The One Health Initiative has provided individuals in many disciplines to collaborate and advance multiple fields of science to study and advance knowledge of zoonotic diseases, antimicrobial resistance, food safety and security and environmental factors. We look forward to providing updates and perspective on this initiative in the future.
The One Health Initiative provides opportunity for collaboration between veterinary and human physicians and researchers to advance both fields.
Source: https://onehealthinitiative.com/about/[vc_single_image image=”3888″ img_size=”600×427″ onclick=”custom_link” link=”https://onehealthinitiative.com/about/”]
A ‘consumer advocate’ recently stirred up drama from July 2017 re-circulating an article (figure 1) claiming that Earth Animal No-Hide® treats were rawhide, again. This was on the heels of the announcement of a class-action lawsuit (figure 2) against Earth Animal Ventures (EAV) questioning the ingredients and sourcing of No-Hide® products. I didn’t think I would have to address this issue, but apparently, I do since misinformation and cherry-picked information from the original chain of events keeps circulating (if it’s on the internet it must be true, right?). Consumers and retailers alike need to see the situation for what it is, so I’ll also write this from both a retailer and consumer standpoint to provide the level of transparency I hold others to. As you read this, you’ll understand that both sides have significant issues. In fact, No-Hide® being (or not being) rawhide is hardly the issue. Instead there is a pervasive lack of transparency and misinformation from both the consumer advocate side and EAV.
The benefit and necessity of grain-free pet food have come under scrutiny in recent years due to an FDA investigation due to a potential association with a canine heart disease known as dilated cardiomyopathy (DCM). As a result of this potential association, many have been told there is no scientific evidence to support the use of grain-free foods in canines and felines, or that these foods do not provide any benefit over grain-inclusive foods. For the most part, grain-free refers to kibble, although some have also categorized various canned, freeze-dried, and raw diets under the ‘grain-free’ umbrella. But are these claims accurate? Let’s find out:
The pet food industry’s switch to grain-free was not fueled by a problem with the grains themselves or grain allergies like most believe. The largest pet food recalls in history was due to melamine and cyanuric acid contamination of ingredients coming from China. The short version of the 2007 recall is that wheat gluten and rice protein were intentionally combined with melamine for its high nitrogen content. Higher amounts of nitrogen can cause the protein content of an ingredient to test higher than it actually is. Since cyanuric acid was present, and the combination of melamine and cyanuric acid is likely the reason the recall was so deadly – not the melamine on its own. This series of events fueled the consumer trend of wanting grain-free pet food.
Another major factor absent from the discussion on grain-free vs. grain inclusive diets for people – and pets – is the contamination of grains with herbicides, pesticides, mycotoxins, and fertilizers. This has become an increasingly large concern since the mid-’90s in both the human and animal food supply. Numerous peer-reviewed articles are detailing the disruption many of these agricultural contaminants have on normal gut bacteria function.1,2 In fact, available literature suggests that humans are becoming increasingly intolerant to grain and grain products for exactly these reasons (e.g. wheat & gluten sensitivity & celiac disease in humans).
We are learning that disruption of vital gut bacteria balance can have devastating effects on the health of the host, including diabetes, obesity, autoimmune disease, cancers, GI issues, and even DCM.3–5 Could the contamination of grains in pet food be one reason why many pets experience improvement of various issues with the change from grain-inclusive to grain-free? Could be.
Ultimately the phrase ‘there is no evidence to support the use of grain-free foods’ doesn’t mean there is not a benefit. It simply means that we have a major gap in research into companion animal nutrition and that we easily forget our recent history. On the contrary, we don’t have evidence to support that feeding grains to canines or felines are any more healthful than feeding grain-free diets. Evidence only shows that it meets minimal (known) nutritional standards, not that pets thrive on these processed diets. In short, canine and feline nutrition fields are far behind the knowledge we have in livestock and human nutrition.
Many veterinarians and pet owners automatically lump grain-free cans, fresh food, raw food, and freeze-dried products as ‘grain-free’. While this is technically correct – there are stark differences that make these foods different from their kibble counterparts.
Regardless of whether we are feeding grain-free or not, we need to consider the high temps kibble and canned foods are heated to during the manufacturing process. This high heat creates Maillard Reaction Products (MRP) which is the name for a series of reactions that is the product of sugar (carbohydrate) and protein when heated. These are also known as AGE’s or Advanced Glycation End Products.
MRP’s are responsible for the nutrient loss and associated with diseases like diabetes, cardiovascular disease, kidney disease, loss of cognitive function, allergies, periodontal disease, and chronic inflammation.6–12 This can mean things like arthritis, skin, and ear issues, an old injury that keeps resurfacing, bloating, IBS, etc. Also, there is a large amount of research to suggest that they are carcinogenic and accelerate aging.13,14
Pet food can be made of everything from rendered unfit foods for human consumption to ingredients that are 100% organic and probably better than the food we feed ourselves. I’m not necessarily here to split hairs on ingredients and in the types of ingredients that are in our pet’s food. Because is it these ingredients that are causing the problem? Or is it something else? – These are the questions that the experts seem to avoid entirely. When a dog experiences issues related to food, we are quick as a society to turn over the bag and blame an ingredient or set of ingredients. However, those ingredients as listed are likely not the problem – rather the quality, processing agents, AGE’s and contamination of these ingredients (e.g. herbicides, pesticides, etc.); something you will never find listed on a label.
The digestibility of food is altered as it is processed, mixed with other ingredients, and heated. That said, canned and kibble foods by definition will have varying levels of nutrient availability and digestibility than their lesser processed counterparts. The ingredients (or set of ingredients) that make up a food could be the most nutrient-dense food available – but if they are not digestible by the cat or dog then those ingredients are irrelevant. In short, this means that it is important to ask your pet food company for their digestibility and nutrient analysis to determine if their food is adequate for your pet. Learn more about what questions to ask and why here.
Nicci is the owner of award-winning NorthPoint Pets & Company, in Connecticut. She is also the Founder & CEO of Undogmatic Inc. Her undergraduate and graduate education includes biology, chemistry, business, and nutrition. She has worked in the pharmaceutical industry on multiple R&D projects and has had the privilege to learn from leading international figures in the human and pet health industry. She regularly lectures at national conferences, including federal, state, and municipal K9 events. Her current research involves identifying pathogenic risk factors and transmission among raw fed pets through a comprehensive worldwide survey.
In part II we discussed phytoremediation, and why this is one of the largest hidden risks for those who give CBD to their pets or consume it themselves. To review, cannabis absorbs heavy metals, and many of the agricultural chemicals in the soil such as pesticides, herbicides, and fertilizers. If a company does not have processes and procedures in place that ensure their product is free from contaminants and is actually the concentration that is listed on the label. Don’t believe this is a real issue? Due to a lack of regulation, hemp products have the potential for significant risks.
Unfortunately, due to the phytoremediation properties of hemp, contaminants and formulation errors are common and often go unnoticed. For example, a recent study by Cornell University showed 10 out of 29 CBD products tested were within 10% of the concentration on the label. That same study also showed that heavy metal contaminants were found in 4 out of 29 products.19 Stop and read that again – because it means that only 34% of the most popular CBD’s were even the correct concentration. Never mind those with contamination issues…Yikes!
Spoiler alert: these are some of the most popular pet CBD supplements on the market today. Most of them are sold locally to Cheshire – so you may want to pay attention.
Lack of regulation for CBD means that companies who are NOT members of the NASC are not required to test raw ingredients or finished products for contaminants or adequacy. Heavy metal contamination, poor sourcing, and/or formulation errors could potentially be a contributing factor to elevated liver function testing and other documented adverse effects relating to hemp & CBD use. This highlights the need to screen companies for adequate product testing and transparency. The reality is that a very small handful of companies can provide verification that their products are contaminant-free, or within concentrations listed on the label.
When looking for a CBD product, or any supplement for yourself or your pets you must ask the following questions:
If companies are unwilling to transparently ask these questions or use the excuse of information being proprietary, I would strongly suggest that you find another brand. Not being transparent or testing products when it comes to ensuring safety is unacceptable. Brands that are not meeting these standards could potentially be poisoning the market for other companies who do their due diligence. As consumers, demand better.
CBD may have its benefits when well-sourced and formulated. While more research is needed, this is a common problem for a lot of supplements and pharmaceuticals on the market. Overall, the risk of adverse effects appears to be low, but consideration should be taken for those pets who may have liver problems.
Some veterinarians are well educated in the CBD landscape and available products, and some simply are not. If your vet is unable to provide information or recommend products it is ok to ask them for someone who can. Many reputable companies do have veterinarians and scientists on-staff that you or your veterinarian may also be able to speak to for more information.
As always, this is a rapidly evolving field. We expect to see changes as the FDA and AVMA begin to release more guidance and information in this area. We also will see more research regarding safety, efficacy, and other applications as time goes on. While it can be frustrating to see both advice and information change, remember this is a good thing and something you should embrace and support!
Did you miss part I, II, III of this series?
Nicci is the owner of award-winning NorthPoint Pets & Company, in Connecticut. She is also the Founder & CEO of Undogmatic Inc. Her undergraduate and graduate education includes biology, chemistry, business, and nutrition. She has worked in the pharmaceutical industry on multiple R&D projects and has had the privilege to learn from leading international figures in the human and pet health industry. She regularly lectures at national conferences, including federal, state, and municipal K9 events. Her current research involves identifying pathogenic risk factors and transmission among raw fed pets through a comprehensive worldwide survey.
References
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